Littleroot Town is located in southwestern Hoenn. It is where players of the Hoenn-based games start their Pokémon journeys. Hoenn's region-exclusive professor, Professor Birch, has a laboratory in the town that he uses for research on Pokémon.
The only exit of the town is north, which leads to Route 101 and Oldale Town beyond. A person will block off this exit until the player has met Brendan/May in the house opposite the player's own.